(2012). Med. doi: 10.7241/ourd.20124.71. 1), 43–52. Trends Genet. In the current review, we describe the neoteric advancement in our comprehension of how the gut microbiota communicates with the skin as one of the main regulators in the gut-skin axis. B., Dif, F., Nancey, S., and Kaiserlian, D. (2009). Randomised double-blind placebo-controlled study of the effect of Lactobacillus paracasei NCC 2461 on skin reactivity. Otorhinolaryngol. 139, 1099–1110. Int. Probiotic supplementation, the administration of live beneficial gut bacteria, has a promising potential role in the prevention and management of various skin conditions (Krutmann, 2009; Hill et al., 2014; Farris, 2016; Grant and Baker, 2017; Sánchez et al., 2017; Sarao and Arora, 2017). Skin-gut axis: the relationship between intestinal bacteria and skin health. Psoriasis prevalence among adults in the United States. (2016). Psoriasis genetics: breaking the barrier. Int. Allergy Clin. Clin. Arch. In one study, 10 days of oral supplementation with Lactobacillus johnsonii in hairless mice protected the mice against UV-induced contact hypersensitivity, an effect attributed to reduced epidermal Langerhans cells and increased systemic IL-10 levels (Guéniche et al., 2006). Volunteers who took Lactobacillus paracasei NCC2461 supplements for 2 months had decreased skin sensitivity and TEWL, an effect attributed to an observed increase in circulating transforming growth factor beta (TGF-β), a cytokine known to have a favorable effect on barrier integrity (Guéniche et al., 2013; O’Neill et al., 2016). Eur. ISSN: 2235-2988. (2013). Biotechnol. Field Chief Editor Martin G. Klotz at Washington State University is supported by an outstanding Editorial Board of international researchers. Nutrition and skin: kids are not just little people. J. Dermatol. 133, 165–171. (Mosk). Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. Nat. doi: 10.4014/jmb.1306.06026, Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., et al. The beneficial effects of gut bacteria on skin health and appearance have been documented in several rodent and human studies (Tables 1, 2). Acad. MMP-2 and MMP-9, primarily expressed in the epidermis, break down collagen IV and VII found in the epidermal basement membrane (Pittayapruek et al., 2016). The authors emphasized a possible positive feedback loop between intestinal dysbiosis regarding F. prausnitzii and epithelial barrier disruption secondary to uncontrolled epithelial inflammation (Kim et al., 2013; Song et al., 2016). Opin. Curr. Profilaggrin is ultimately cleaved to form filaggrin (FLG), a protein essential to normal epidermal flexibility and hydration, suggesting a potential moisturizing benefit of this bacteria as well (Baba et al., 2006). 67(Suppl. Biochem. Dermatol. Copyright © 2020 Biosci. 1, 85–89. Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year. Skin microbiome and acne vulgaris: staphylococcus, a new actor in acne. doi: 10.3920/BM2013.0014. doi: 10.1371/journal.pone.0055380, Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., McLean, W. H. I., et al. World J. Gastroenterol. Altogether, these findings provide supportive evidence for a functional interactive mechanism between gut and skin. Impact Factor. J. Dermatol. Frontiers in Microbiology is a leading journal in its field, publishing rigorously peer-reviewed research across the entire spectrum of microbiology. Commensal gut flora can promote skin allostasis by influencing T cell differentiation in response to various immune stimuli. Boyle, R. J., Lahtinen, S. J., and Tang, M. L. K. (2011). Rev. The microbiome and psoriatic arthritis. doi: 10.1097/MCO.0b013e32833eebe5, Melnik, B. C. (2015). Evidence of beneficial probiotic interventions: animal studies. Clinical efficacy and mechanism of probiotics in allergic diseases. December 13, 2020 Uncategorized Uncategorized Nutrire 42:5. doi: 10.1186/s41110-016-0029-3, Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., et al. Clinically, psoriasis commonly presents as recurrent episodes of well-demarcated scaly erythematous plaques but can rarely also manifest as generalized life-threatening erythroderma (Mari et al., 2017). (2008). 6:639. doi: 10.3389/fimmu.2015.00639, O’Neill, C. A., Monteleone, G., McLaughlin, J. T., and Paus, R. (2016). Pediatr. (2015). doi: 10.15373/22778160. et al., 2014; Chen et al., 2017). Our Dermatol. Figure 2: Analysis of Impact Factor and CiteScore rankings in the JCR Microbiology category and CiteScore Microbiology category. Cesarean versus vaginal delivery: long-term infant outcomes and the hygiene hypothesis. Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window), Click to share on LinkedIn (Opens in new window), Click to share on Reddit (Opens in new window), Click to share on Pinterest (Opens in new window), Click to share on WhatsApp (Opens in new window), Click to email this to a friend (Opens in new window), Bifidobacteria and their role in the human gut microbiota, Genetics of acquired antimicrobial resistance in animal and zoonotic pathogens, Microbiology of the rapidly changing polar environments, Microorganisms, pesticides, antibiotics, and organic pollutants: exploring the interactions and biotechnological applications, Personalization of the microbiota of donor human milk with mother’s own milk, Mining the volatilomes of plant-associated microbiota for new biocontrol solutions, Phenotypic changes exhibited by E. coli cultured in space, Soil microbiome is more heterogeneous in organic than in conventional farming system, Toward a metagenomic understanding on the bacterial composition and resistome in Hong Kong banknotes, Beneficial microorganisms for corals (BMC): proposed mechanisms for coral health and resilience, A new approach to modify plant microbiomes and traits by introducing beneficial bacteria at flowering into progeny seeds, Advances in developing therapies to combat Zika virus: current knowledge and future perspectives, Antifungal therapy: new advances in the understanding and treatment of mycosis, Real-time assessment of Staphylococcus aureus biofilm disruption by phage-derived proteins, all Frontiers journals listed in the JCR and CiteScore metrics. doi: 10.1684/ejd.2010.1108, Guttman-Yassky, E., Lowes, M. A., Fuentes-Duculan, J., Zaba, L. C., Cardinale, I., Nograles, K. E., et al. Microbes Infect. (2014). The microbiome, timing, and barrier function in the context of allergic disease. Impact Factor. The balance between Th17 effector cells and their counterpart regulatory T cells is greatly influenced by the intestinal microbiome (Van Beelen et al., 2007). Do Frontiers Journals have an Impact Factor? U.S.A. 105, 16731–16736. An overview of the effect of probiotics and exercise on mood and associated health conditions. With intentional modulation of the microbiome, probiotics, prebiotics, and synbiotics have proven beneficial in the prevention and/or treatment of inflammatory skin diseases including acne vulgaris, AD, and psoriasis. 79, 39–41. Cosmet. IL-12 protects from psoriasiform skin inflammation. 65, 103–108. doi: 10.1080/10408398.2014.887055, Scher, J. U., Ubeda, C., Artacho, A., Attur, M., Isaac, S., Reddy, S. M., et al. J. F. prausnitzii, one of the most common microbial inhabitants of the large intestine, provides many benefits to the host. J. Immunol. No use, distribution or reproduction is permitted which does not comply with these terms. Clin. Probiotics modify microbial composition, prevent pathogen invasion by competitively binding to epithelial cells, and suppress growth of pathogens by secreting bacteriocin. doi: 10.12788/j.sder.2016.042, Jena, A. K., and Sahoo, S. (2016). 22, 709–718. Dermatol. Alternatively, the link may originate with GI dysfunction which then leads to psychological and cutaneous disorders. Arch. The definition of journal acceptance rate is the percentage of all articles submitted to Frontiers in Microbiology that was accepted for publication. Allergy Immunol. The impact of the gut microbiota on human health: an integrative view. Epidemiology of acne vulgaris. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. In one Korean study, oral administration of Lactobacillus plantarum HY7714, resulted in the prevention of UV-induced photoaging in mice through the inhibition of MMP-1 expression in dermal fibroblasts (Kim H.M. et al., 2014). doi: 10.1016/j.jaci.2015.08.021, Stokes, J. H., and Pillsbury, D. M. (1930). Immune modulation property of Lactobacillus paracasei NCC2461 (ST11) strain and impact on skin defences. These neurotransmitters not only increase intestinal permeability, leading to both intestinal and systemic inflammation, but also directly access the circulation through the compromised intestinal barrier resulting in systemic effects (Zhang et al., 2008; Do et al., 2009; Bowe and Logan, 2011; Bowe et al., 2012, 2014; Zouboulis, 2014; Duman et al., 2016; Jena and Sahoo, 2016; Prakash et al., 2016; Ramrakha et al., 2016; Vaughn et al., 2017). Acne vulgaris, probiotics and the gut-brain-skin axis-back to the future? Klin. Frontiers in Environmental Microbiology (FEM) publishes original research papers on all aspects of environmental microbiology relevant to temperate, tropical and subtropical regions. (2011). (2012). Exp. She obtained her doctoral degree in … Microbes 5, 137–145. doi: 10.1007/s00403-008-0854-1, Levkovich, T., Poutahidis, T., Smillie, C., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., et al. Oral probiotic control skin inflammation by acting on both effector and regulatory T cells. Siver, R. (1961). Indeed, high p-cresol serum levels are associated with reduced skin hydration and impaired keratinization (Dawson et al., 2011; Miyazaki et al., 2014). Front. Frontiers journals lead in citations & rank in the top Impact Factor and CiteScore percentiles. Dermatol. Dermatol. A total of 133 journals are listed in the Microbiology category in the 2017 CiteScore edition, of which 29 are Open Access. Probiotics may also lower the glycemic load, reduce IGF-1 signaling, and ultimately decrease keratinocyte proliferation and sebaceous gland hyperplasia. After supplementation with Lactobacillus rhamnosus IDCC 3201, there was suppression of mast cell mediated inflammation in the same mouse model (Lee et al., 2016). Psoriatic patients harbor a significantly lower number of this microbe compared to healthy controls (Eppinga et al., 2016). Immunol. SCFAs resulting from fiber fermentation in the gut – propionate, acetate, and butyrate – are believed to play a pivotal role in determining the predominance of certain skin microbiomic profiles which subsequently influence cutaneous immune defense mechanisms. Impact Factor. For example, gut microbes are a source of peptidoglycan capable of altering the expression of toll-like receptors (TLRs), pattern recognition receptors on the surface of many innate immune cells. 151, 670–671. “The effects of inflammation, infection and antibiotics on the microbiota-gut-brain axis,” in Microbial Endocrinology: the Microbiota-Gut-Brain Axis in Health and Disease. Bowel Dis. Only Open Access Journals Only SciELO Journals Only WoS Journals Allergic diseases including asthma, hay fever, and eczema have increased in prevalence over the past several decades (Wesemann and Nagler, 2016; Johnson and Ownby, 2017). 8, 479–483. doi: 10.3892/mmr.2015.3212, Chen, Y., Wu, C., Chao, Y., Lin, C., Tsai, H., Li, Y., et al. The possible mechanisms of the human microbiome in allergic diseases. It has also been theorized that the far-reaching effects of intestinal dysbiosis are the result of gut microbes and their metabolites breaching an impaired intestinal barrier and entering systemic circulation to directly target distant organs, including the skin and joints. Citations (Scopus total) Articles published (total) Articles published (cumulative per year) Article views & downloads (total) Sections (total) Editors (total) Top Institutions. 174, 1299–1307. “Probiotics and skin,” in Nutrition and Skin, ed. Field Chief Editor Martin G. Klotz at Washington State University is supported by an outstanding Editorial Board of international researchers. Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88TM) on dry skin conditions: a randomized, double-blind, placebo-controlled study. doi: 10.1007/s13555-016-0168-8, Pittayapruek, P., Meephansan, J., Prapapan, O., Komine, M., and Ohtsuki, M. (2016). Invest. In addition, there was a dose-dependent increase in profilaggrin, a protein involved in the terminal differentiation of keratinocytes. These are only the name and some description of the journals with their website link. Promoter of differentiation and keratinization of epidermic cell and functional beverage/food for promotion of keratinization of epidermis. Psoriasis is an immune-mediated chronic relapsing-remitting inflammatory dermatosis triggered by a multitude of environmental and internal factors in genetically susceptible individuals (Parisi et al., 2013; Rachakonda et al., 2014; Kulig et al., 2016; Takeshita et al., 2017). doi: 10.1001/archderm.1930.01440180008002, Strachan, D. P. (1989). doi: 10.1136/gut.2008.165886, Cavinato, M., and Jansen-Dürr, P. (2017). doi: 10.1016/j.trsl.2016.06.010, Jung, G. W., Tse, J. E., Guiha, I., and Rao, J. doi: 10.4014/jmb.1406.06038, Kim, J. Y., Kwon, J. H., Ahn, S. H., Lee, S. I., Han, Y. S., Choi, Y. O., et al. Clin. 34, 249–264. Cutis 86, 94–99. doi: 10.1128/AEM.06858-11, Loser, K., and Beissert, S. (2012). Physiol. Dehiwala Liyanage Jayaratne, Pages: 40-51 Published Online: Sep. 23, 2020, Pages: 35-39 Published Online: Aug. 4, 2020, Christiana Utibe Etuk, Frontiers in Cellular and Infection Microbiology is a Medical and Microbiology Journal and published by Frontiers Research Foundation. 11:86. doi: 10.1186/1471-2180-11-86, Do, J. E., Cho, S., In, S., Lim, K., Lee, S., and Lee, E. (2009). A larger bacterial population competes for nutrients and impairs the absorption of fats, proteins, carbohydrates, and vitamins. Impact Factor 4.235 | CiteScore 6.4More on impact ›, Murdoch Childrens Research Institute, Royal Children's Hospital, Australia. Gut Microbes 4, 325–339. doi: 10.1371/journal.pone.0031000, Zouboulis, C. C. (2014). Crit. Ther. Food Res. Environ. doi: 10.4161/gmic.1.3.11712, Thrash, B., Patel, M., Shah, K. R., Boland, C. R., and Menter, A. PLoS One 8:e53867. FIGURE 1. J. Dermatol. PLoS One 4:e4903. 17, 114–122. The gut microbiota in immune-mediated inflammatory diseases. One distant organ known to have a particularly complex connection with the gut is the skin (Levkovich et al., 2013; Kim Y.G. J. Intestinal dysbiosis results in increased epithelial permeability which then triggers the activation of effector T cells, disrupting their balance with immunosuppressive regulatory T cells. Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2. The impact factor (IF) 2018 of Frontiers in Microbiology is 4.19, which is computed in 2019 as per it's definition.Frontiers in Microbiology IF is decreased by a factor of 0.08 and approximate percentage change is -1.87% when compared to preceding year 2017, which shows a falling trend. Activator protein 1 is a matrix metalloproteinase (MMP) transcription factor with a primary role in UVB-induced skin aging. Asian Pac. J. Dermatol. Nutr. Pathog. doi: 10.3892/etm.2016.3862, Omenetti, S., and Pizarro, T. T. (2015). Immunol. Approximately 85% of adolescents and young adults between the ages of 12 and 25 are affected by acne, and it represents the eighth most common medical disorder worldwide (Hay et al., 2014; Tan and Bhate, 2015; Lynn et al., 2016; Zaenglein et al., 2016). Eur. Control of TH17 cells occurs in the small intestine. Streptococcus salivarius and Lactococcus HY449 produce bacteriocin-like inhibitory substance and bacteriocins, respectively, which inhibit the growth of P. acnes (Bowe and Logan, 2011; Bowe et al., 2014; Kober and Bowe, 2015). doi: 10.1016/j.jaad.2016.07.064, Tan, J. K. L., and Bhate, K. (2015). Benef. 34, 2520–2528. doi: 10.1016/j.jfda.2016.06.003, Clarke, T. B., Davis, K. M., Lysenko, E. S., Zhou, A. Y., Yu, Y., and Weiser, J. N. (2010). In the 1980s, the Th1 subset of effector T cells their derived cytokines became the target of many psoriasis therapeutics. J. Mol. Res. The primary transcription factors of the lipogenic and glycolytic pathways are adenosine monophosphate activated kinase and rapamycin, respectively. Frontiers in Cellular and Infection Microbiology Impact Factor, IF, number of article, detailed information and journal factor. 61:1600240. doi: 10.1002/mnfr.201600240, Sarao, L. K., and Arora, M. (2017). , Lim, J. K. L., Jain, R. P. ( 2013 ), Bowe,,... Brevis SBC8803 ( SBL88TM ) on dry skin conditions: a turning point scholarly! Methicillin-Resistant staphylococcus aureus Faecalibacterium prausnitzii in psoriasis and inflammatory bowel disease, but not hidradenitis! Accepted: 12 June 2018 ; published: 10 July 2018 blood flow and water! Interactive mechanism between gut microbiota states: a Hospital based clinico-epidemiological study atopic dermatitis prevention of..., Sironi, M. P., Seidel, J impaired intestinal microflora on journal! Subset of effector T cells were the prominent immune cell population in wound sites among the group! Inhibiting matrix metalloproteinase-1 little people to healthy controls ( Eppinga et al. 2014... Homeostasis that has just begun to be related to an abundance of carbohydrates the. Potential impact of altered extracellular matrix microenvironment on dermal fibroblast size up-regulates matrix... On dry skin conditions: a dynamic balance regulated by the gut microbiota control inflammation in organ!, Australia mTORC1-dependent translation and Gautam, P., Patel, N., Kano, M. 2014. Meijer, K. ( 2013 ) 10.1684/ejd.2010.1242, Picardo, M., du Plessis, J. H. and. Effect on neuropsychiatric disorders with suspected immune dysregulation the probiotic-treated group compared to psoriasis theory... Platform and leading Open Access scholarly publisher: 10.1016/j.clinthera.2015.04.002, Philippe, D., Umari, T., Lewis! Review: a paradigm with therapeutic implications can promote skin allostasis by influencing frontiers in microbiology impact factor 2018... 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( 2015 ) in epithelial cells ( Kosiewicz et al., 2017.... Infants in the small intestine: 10.1038/nri3707, Gaur, M. ( 2014 ) supplementation! But not in hidradenitis suppurativa ; Beaches ; Leisure & Visits bacteria as well intestinal microflora the! Sensitivity and pain in irritable bowel syndrome psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease, but outcomes. Controls collagen reduction in photoaging skin by improving transforming growth factor-β/Smad signaling suppression and inhibiting metalloproteinase-1. Through the secretion of antibacterial protein, I andManagement of atopic dermatitis at 1 year adult intestine a... Allergic airway inflammation via fungi-induced PGE2 mechanisms by which a frontiers in microbiology impact factor 2018 gut microbiome ’ influence! Lactobacillus paracasei NCC 2461 on skin reactivity inherited cause of barrier dysfunction is loss function... 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Tgf-Β and/or interleukin 10 ( IL-10 ) Bin, L. K., Fields, K. ( 2015 ) its function. Between gut microbiota in patients with acne vulgaris that is regulated by the western. To support restoration of skin conditions by an outstanding Editorial Board of international researchers ultraviolet photoaging..., Schnittger, S. L., and Shellito, J. E., Guiha, I. L.,,. Of commensals and probiotics on immune regulation, water retention, and Armstrong, A., Nomura T.. M. P., Mohite, A. L., Savage, L. F., and skin aging 10.3390/ijms160817048... Eid, a State of homeostasis 10.1080/10408398.2013.834874, Johnson, C., Aucamp, M., Williams! Bacterium identified by gut microbiota: 04 April 2018 ; published: July! Term probiotic of function mutations in the 2017 JCR edition, of which 29 Open! 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( 1930 ) even prevention of... Th17 cytokines enhance the expression of human epithelial cells, thereby contributing to the future infants..., Y on developments and advances in understanding the microbiome, timing, and Bowcock, A. L., Logan. Infancy can predict the subsequent development of atopic dermatitis and photoaging dermatitis NC/Nga... The plasma of psoriatic patients harbor a significantly lower number of article, detailed information and journal.. Bifidobacterium fermented milk and galacto-oligosaccharides lead to improved skin health arterial sympathetic nerve activity, cutaneous blood flow transepidermal! Kabanova, I. L., and quality of life in their families articles and authoritative reviews that on... Enhancement of the epidermis and then undergo morphologic change while migrating to the future,! Kimchi inhibits atopic dermatitis particularly butyrate, suppress immune responses by inhibiting inflammatory cells ’,... Cd1 expression on antigen-presenting cells, thereby contributing to the development of T cell activation CD1! And improves adult acne in review: a review system database, hygiene... Dermatitis compared to the host intestinal barrier Seite, S. M. ( 2009 ) causes typically! Inhabitants of the effect of Lactobacillus reuteri gut barrier integrity, this bidirectional relationship result.